⁸⁹Zr-labeled ImmunoPET targeting the cancer stem cell antigen CD133 using fully-human antibody constructs.

ABSTRACT:

Background

Cancer stem cells play an important role in driving tumor growth and treatment resistance, which makes them a promising therapeutic target to prevent cancer recurrence. Emerging cancer stem cell-targeted therapies would benefit from companion diagnostic imaging probes to aid in patient selection and monitoring response to therapy. To this end, zirconium-89-radiolabeled immunoPET probes that target the cancer stem cell-antigen CD133 were developed using fully human antibody and antibody scFv-Fc scaffolds.

Results

ImmunoPET probes [⁸⁹Zr]-DFO-RW03_IgG (CA = 0.7 ± 0.1), [⁸⁹Zr]-DFO-RW03_IgG (CA = 3.0 ± 0.3), and [⁸⁹Zr]-DFO-RW03_{scFv - Fc} (CA = 2.9 ± 0.3) were radiolabeled with zirconium-89 (radiochemical yi

SUBMITTER: Wyszatko K 

PROVIDER: S-EPMC10948676 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature