Translating NIA-AA criteria into usual practice: Report from the ReDeMa Project.

ABSTRACT:

Introduction

Biomarker-informed criteria were proposed for the diagnosis of Alzheimer's disease (AD) by the National Institute on Aging and the Alzheimer's Association (NIA-AA) in 2011; however, the adequacy of this criteria has not been sufficiently evaluated.

Methods

ReDeMa (Red de Demencias de Madrid) is a regional cohort of patients attending memory and neurology clinics. Core cerebrospinal fluid biomarkers were obtained, NIA-AA diagnostic criteria were considered, and changes in diagnosis and management were evaluated.

Results

A total of 233 patients were analyzed (mean age 70 years, 50% women, 73% AD). The diagnostic language was modified significantly, with a majority assumption of NIA-AA definitions (69%). Confidence in diagnosis increased from 70% to 9

SUBMITTER: Sanchez-Soblechero A 

PROVIDER: S-EPMC10948948 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature