Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors.

ABSTRACT:

Importance

Children undergoing treatment for leukemia are at increased risk of severe sepsis, a dysregulated immune response to infection leading to acute organ dysfunction. As cancer survivors, they face a high burden of long-term adverse effects. The association between sepsis during anticancer therapy and long-term organ dysfunction in adult survivors of childhood cancer has not been examined.

Objective

To determine whether severe sepsis during therapy for leukemia in childhood is associated with subsequent chronic health conditions in adult survivors.

Design, setting, and participants

This cohort study included 644 adult survivors of childhood leukemia who were diagnosed between January 1, 1985, and July 19, 2010, and participated in the St Jude Lifetime Cohort St

SUBMITTER: Goggin KP 

PROVIDER: S-EPMC10949094 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature