Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy.

ABSTRACT:

Importance

Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring.

Objective

To investigate the prevalence of MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes in MCM prevalence over time.

Design, setting, and participants

This was a prospective, observational, longitudinal cohort study conducted from June 1999 to October 2022. Since 1999, physicians from more than 40 countries enrolled ASM-treated WWE before pregnancy outcome was known and followed up their offspring until 1 year after birth. Participants aged 14 to 55 years who were exposed to 8 of the most frequently used ASMs during pregna

SUBMITTER: Battino D 

PROVIDER: S-EPMC10949148 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature