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A Modular Approach for the Synthesis of Diverse Heterobifunctional Cyanine Dyes.

ABSTRACT: Herein, we present a straightforward synthetic route for the design and synthesis of diverse heterobifunctional cyanine 5 dyes. We optimized the workup by harnessing the pH- and functional group-dependent solubility of the asymmetric cyanine 5 dyes. Therefore, purification through chromatography is deferred until the last synthesis step. Demonstrating successful large-scale synthesis, our modular approach prevents functional group degradation by introducing them in the last synthesis step. These modifiable heterobifunctional dyes offer significant utility in advancing biological studies.

SUBMITTER: Maller C

PROVIDER: S-EPMC10949230 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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A Modular Approach for the Synthesis of Diverse Heterobifunctional Cyanine Dyes.

Maller Corina C Schedel Franziska F Köhn Maja M

The Journal of organic chemistry 20240227 6

Herein, we present a straightforward synthetic route for the design and synthesis of diverse heterobifunctional cyanine 5 dyes. We optimized the workup by harnessing the pH- and functional group-dependent solubility of the asymmetric cyanine 5 dyes. Therefore, purification through chromatography is deferred until the last synthesis step. Demonstrating successful large-scale synthesis, our modular approach prevents functional group degradation by introducing them in the last synthesis step. These ...[more]

PMID: 38413005

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