Ontology highlight
ABSTRACT:
SUBMITTER: Madiu R
PROVIDER: S-EPMC10949238 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Madiu Rufai R Doran Erin L EL Doran Jenna M JM Pinarci Ali A AA Dhillon Kiran K Rivera Dominic A DA Howard Amari M AM Stroud James L JL Moskovitz Dylan A DA Finneran Steven J SJ Singer Alyssa N AN Rossi Morgan E ME Moura-Letts Gustavo G
The Journal of organic chemistry 20240226 6
Herein, we report the catalytic allylic amination of α-methylalkenes with V<sub>2</sub>O<sub>3</sub>Dipic<sub>2</sub>(HMPA)<sub>2</sub> and chloramine T as the quantitative source of <i>N</i>. The reaction works with high yields and stereoselectivities for α-methylalkenes. A proposed tosylnitrene-free catalytic cycle involving the formation of vanadoxaziridine complex <b>1</b> as the active catalyst and aminovanadation across the substrate as the rate-determining step has been proposed. Initial ...[more]