COVID-19 in patients with Down syndrome: A systematic review.

ABSTRACT:

Introduction

Down syndrome (DS) is associated with multiple comorbid conditions and chronic immune dysfunction. Persons with DS who contract COVID-19 are at high risk for complications and have a poor prognosis. We aimed to study the clinical symptoms, laboratory and biochemical profiles, radiologic findings, treatment, and outcomes of patients with DS and COVID-19.

Method

We systematically searched PubMed, MEDLINE, Web of Science, Scopus, and the Cochrane Library using the keywords COVID-19 or coronavirus or SARS-CoV-2 and DS or trisomy 21. Seventeen articles were identified: eight case reports and nine case series published from December 2019 through March 2022, with a total of 55 cases.

Results

Patients averaged 24.8 years (26 days to 60 years); 29 of the patients

SUBMITTER: Pitchan Velammal PNK 

PROVIDER: S-EPMC10949394 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature