Rational attenuation of canine distemper virus (CDV) to develop a morbillivirus animal model that mimics measles in humans.

ABSTRACT: Morbilliviruses are members of the family Paramyxoviridae and are known for their ability to cause systemic disease in a variety of mammalian hosts. The prototypic morbillivirus, measles virus (MeV), infects humans and still causes morbidity and mortality in unvaccinated children and young adults. Experimental infection studies in non-human primates have contributed to the understanding of measles pathogenesis. However, ethical restrictions call for the development of new animal models. Canine distemper virus (CDV) infects a wide range of animals, including ferrets, and its pathogenesis shares many features with measles. However, wild-type CDV infection is almost always lethal, while MeV infection is usually self-limiting. Here, we made five recombinant CDVs, predicted to be attenuated, an

SUBMITTER: Schmitz KS 

PROVIDER: S-EPMC10949419 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature