Multidrug resistance plasmids commonly reprogram the expression of metabolic genes in Escherichia coli.

ABSTRACT: Multidrug-resistant Escherichia coli is a leading cause of global mortality. Transfer of plasmids carrying genes encoding beta-lactamases, carbapenamases, and colistin resistance between lineages is driving the rising rates of hard-to-treat nosocomial and community infections. Multidrug resistance (MDR) plasmid acquisition commonly causes transcriptional disruption, and while a number of studies have shown strain-specific fitness and transcriptional effects of an MDR plasmid across diverse bacterial lineages, fewer studies have compared the impacts of different MDR plasmids in a common bacterial host. As such, our ability to predict which MDR plasmids are the most likely to be maintained and spread in bacterial populations is limited. Here, we introduced eight diverse MDR plasmids e

SUBMITTER: Hall RJ 

PROVIDER: S-EPMC10949484 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature