Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.

ABSTRACT: Herpes simplex virus-1 (HSV-1) infections are among the most frequent serious viral eye infections in the U.S. and are a major cause of viral-induced blindness. HSV-1 infection is known to induce T cell activation, proliferation, and differentiation that play crucial roles in the development of virus-induced inflammatory lesions, leading to eye disease and causing chronic corneal damage. CD80 is a co-stimulatory molecule and plays a leading role in T cell differentiation. Previous efforts to limit lesion severity by controlling inflammation at the cellular level led us to ask whether mice knocked out for CD80 would show attenuated virus replication following reactivation. By evaluating the effects of CD80 activity on primary and latent infection, we found that in the absence of CD80, virus

SUBMITTER: Jaggi U 

PROVIDER: S-EPMC10949485 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature