Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica.

ABSTRACT: The ability of virulent bacteriophages to lyse bacteria influences bacterial evolution, fitness, and population structure. Knowledge of both host susceptibility and resistance factors is crucial for the successful application of bacteriophages as biological control agents in clinical therapy, food processing, and agriculture. In this study, we isolated 12 bacteriophages termed SPLA phage which infect the foodborne pathogen Salmonella enterica. To determine phage host range, a diverse collection of Enterobacteriaceae and Salmonella enterica was used and genes involved in infection by six SPLA phages were identified using Salmonella Typhimurium strain ST4/74. Candidate host receptors included lipopolysaccharide (LPS), cellulose, and BtuB. Lipopolysaccharide was id

SUBMITTER: Acton L 

PROVIDER: S-EPMC10949491 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature