MicroRNA-190b Targets RFWD3 in Estrogen Receptor-Positive Breast Cancer.

ABSTRACT:

Background

In the year 2020, breast cancer was the most common form of cancer worldwide. Roughly 70% of breast cancers are estrogen receptor-positive (ER+). MicroRNA-190b (miR-190b) has previously been reported to be upregulated in ER+ breast cancers. Previously, we have demonstrated that miR-190b is hypomethylated in ER+ breast cancers, potentially leading to its upregulation.

Objectives

To further study the role of miR-190b in ER+ breast cancer and to identify its clinically relevant targets in breast cancer.

Design

Patient cohort and cell line-based RNA-sequencing analysis.

Methods

The Cancer Genome Atlas was used to obtain gene expression data and clinical information on patients with breast cancer. To identify messenger RNA (mRNA) targets for miR-190b, the

SUBMITTER: Frick EA 

PROVIDER: S-EPMC10949548 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature