Tobacco use, self-reported professional dental cleaning habits, and lung adenocarcinoma diagnosis are associated with bronchial and lung microbiome alpha diversity.

ABSTRACT:

Rationale

The lung microbiome is an inflammatory stimulus whose role in the development of lung malignancies is incompletely understood. We hypothesized that the lung microbiome associates with multiple clinical factors, including the presence of a lung malignancy.

Objectives

To assess associations between the upper and lower airway microbiome and multiple clinical factors including lung malignancy.

Methods

We conducted a prospective cohort study of upper and lower airway microbiome samples from 44 subjects undergoing lung lobectomy for suspected or confirmed lung cancer. Subjects provided oral (2), induced sputum, nasopharyngeal, bronchial, and lung tissue (3) samples. Pathologic diagnosis, age, tobacco use, dental care history, lung function, and inhaled corticoster

SUBMITTER: Pragman AA 

PROVIDER: S-EPMC10949571 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature