Prognostic marker CD27 and its micro-environmental in multiple myeloma.

ABSTRACT:

Background

The Cluster of Differentiation 27 (CD27) is aberrantly expressed in multiple myeloma (MM) -derived. This expression facilitates the interaction between tumor and immune cells within TME via the CD27-CD70 pathway, resulting in immune evasion and subsequent tumor progression. The objective of this study is to investigate the correlation between CD27 expression and the prognosis of MM, and to elucidate its potential relationship with the immune microenvironment.

Methods

In this research, CD27 expression in T cells within the 82 newly diagnosed MM microenvironment was assessed via flow cytometry. We then examined the association between CD27 expression levels and patient survival. Subsequent a series of bioinformatics and in vitro experiments were conducted to reveal

SUBMITTER: Wang X 

PROVIDER: S-EPMC10949675 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature