RNA-binding proteins potentially regulate the alternative splicing of apoptotic genes during knee osteoarthritis progression.

ABSTRACT:

Background

Alternative splicing (AS) is a principal mode of genetic regulation and one of the most widely used mechanisms to generate structurally and functionally distinct mRNA and protein variants. Dysregulation of AS may result in aberrant transcription and protein products, leading to the emergence of human diseases. Although considered important for regulating gene expression, genome-wide AS dysregulation, underlying mechanisms, and clinical relevance in knee osteoarthritis (OA) remain unelucidated. Therefore, in this study, we elucidated and validated AS events and their regulatory mechanisms during OA progression.

Results

In this study, we identified differentially expressed genes between human OA and healthy meniscus samples. Among them, the OA-associated genes were

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10949708 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature