Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding.

ABSTRACT:

Background

The host-microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, and microbial tryptophan metabolites are potent modulators of host physiology. However, whether and how these metabolites mediate host-microbiota interactions, particularly in terms of inter-microbial communication, remains unclear.

Results

Here, we have demonstrated that indole-3-lactic acid (ILA) is a key molecule produced by Lactobacillus in protecting against intestinal inflammation and correcting microbial dysbiosis. Specifically, Lactobacillus metabolizes tryptophan into ILA, thereby augmenting the expression of key bacterial enzymes implicated in tryptophan metabolism, leading to the synthesis of other indole derivatives including indole-3-propionic a

SUBMITTER: Wang G 

PROVIDER: S-EPMC10949743 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature