Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation.

ABSTRACT: Electrical stimulation is an effective tool for mapping and altering brain connectivity, with applications ranging from treating pharmacology-resistant neurological disorders to providing sensory feedback for neural prostheses. Paramount to the success of these applications is the ability to manipulate electrical currents to precisely control evoked neural activity patterns. However, little is known about stimulation-evoked responses in inhibitory neurons nor how stimulation-evoked activity patterns depend on ongoing neural activity. In this study, we used 2-photon imaging and cell-type specific labeling to measure single-cell responses of excitatory and inhibitory neurons to electrical stimuli in the visual cortex of awake mice. Our data revealed strong interactions between electrical sti

SUBMITTER: Dadarlat MC 

PROVIDER: S-EPMC10949925 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature