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Switch-on near infrared emission in albumin behind dark fabric: toward application in forensic latent bloodstain detection.

ABSTRACT: Latent bloodstain detection remains imperative for crime scene investigators. Widely used luminol offers high sensitivity to human blood, but can produce untrustworthy results from a bleach-cleaned crime scene or in a room not dark enough. Furthermore, dark pigments impede imaging bloodstains covered by dark materials with previously reported bloodstain detection agents. A novel on/off human albumin-sensing dye (SO3C7) is reported herein with a longer emission wavelength (942 nm) than previous materials that allows imaging behind ∼5 mm of black fabric. The switch-on emission of SO3C7 is selective and sensitive to human albumin and lasts longer than luminol (24-48 hours). Emission studies, transient absorption spectra (TAS), and near-infrared (NIR) photographs herein describe the albumin sensing properties of the dye.

SUBMITTER: Saucier MA

PROVIDER: S-EPMC10949964 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Switch-on near infrared emission in albumin behind dark fabric: toward application in forensic latent bloodstain detection.

Saucier Matthew A MA Kruse Nicholas A NA Lewis Timothy A TA Hammer Nathan I NI Delcamp Jared H JH

RSC advances 20240319 13

Latent bloodstain detection remains imperative for crime scene investigators. Widely used luminol offers high sensitivity to human blood, but can produce untrustworthy results from a bleach-cleaned crime scene or in a room not dark enough. Furthermore, dark pigments impede imaging bloodstains covered by dark materials with previously reported bloodstain detection agents. A novel on/off human albumin-sensing dye (SO3C7) is reported herein with a longer emission wavelength (942 nm) than previous m ...[more]

PMID: 38505385

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