Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities.

ABSTRACT:

Abstract

Anti-cancer therapies usually focus on tumor cells, but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression, which may be the prognostic factors and potential therapeutic targets. Cancer-associated fibroblasts (CAFs) are the essential component in the tumor environment, exhibiting high heterogeneity in their cell origin and phenotype with diverse functions that influence tumor angiogenesis, immune systems, and metabolism. Single-cell RNA sequencing and genetically engineered mouse models have increased our understanding of CAF diversity, and many subtypes have been defined. However, the precise functions of these subtypes need to be studied and validated. Studies of signaling pathways and epigenetic changes i

SUBMITTER: Zhou D 

PROVIDER: S-EPMC10950138 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature