The one-carbon metabolism as an underlying pathway for placental DNA methylation - a systematic review.

ABSTRACT: Epigenetic modifications, including DNA methylation, are proposed mechanisms explaining the impact of parental exposures to foetal development and lifelong health. Micronutrients including folate, choline, and vitamin B₁₂ provide methyl groups for the one-carbon metabolism and subsequent DNA methylation processes. Placental DNA methylation changes in response to one-carbon moieties hold potential targets to improve obstetrical care. We conducted a systematic review on the associations between one-carbon metabolism and human placental DNA methylation. We included 22 studies. Findings from clinical studies with minimal ErasmusAGE quality score 5/10 (n = 15) and in vitro studies (n = 3) are summarized for different one-carbon moieties. Next, results are discuss

SUBMITTER: van Vliet MM 

PROVIDER: S-EPMC10950272 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature