Unknown

Dataset Information

0

Noninvasive Stereotactic Radiotherapy for PADN in an Acute Canine Model of Pulmonary Arterial Hypertension.

ABSTRACT: This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted in reduced mean pulmonary artery pressure, pulmonary capillary wedge pressure, and pulmonary vascular resistance, and insignificantly increased cardiac output. In comparison to the control group, serum norepinephrine levels at 1 month and 6 months were significantly lower in the CyberKnife group. Computed tomography, pulmonary angiography, and histology analysis revealed that SBRT was associated with minimal collateral damage.

SUBMITTER: Xu W 

PROVIDER: S-EPMC10950402 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Noninvasive Stereotactic Radiotherapy for PADN in an Acute Canine Model of Pulmonary Arterial Hypertension.

Xu Wei W   Wang Ding-Yu DY   Chen Zi-Yin ZY   Gao Qiang Q   Zou Yi-Lun YL   Sun Dang-Hui DH   Zhang Song S   Zhao Xin-Bo XB   Gong Yong-Tai YT   Zhang Yun Y   Zhang Da-Xin DX   Li Yue Y  

JACC. Basic to translational science 20231206 2

This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted in reduced mean pulmonary artery pressure, pulmonary capillary wedge pressure, and pulmonary vascular resistance, and insignificantly increased cardiac output. In comparison to the control group, serum norepinephrine levels at 1 month and 6 months were significantly lower in the CyberKni  ...[more]

Similar Datasets

Unknown Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model.
| S-EPMC8196028 | biostudies-literature
Unknown Pulmonary arterial hypertension associated with portal hypertension: Noninvasive comprehensive assessment using computed tomography.
| S-EPMC10726335 | biostudies-literature
Unknown Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension.
| S-EPMC7335577 | biostudies-literature
Unknown Incorporation of noninvasive assessments in risk prediction for pulmonary arterial hypertension.
| S-EPMC9686446 | biostudies-literature
Transcriptomics Blood pulmonary arterial hypertension
2003-11-15 | GSE703 | GEO
Unknown Autoimmune disease mouse model exhibits pulmonary arterial hypertension.
| S-EPMC5605000 | biostudies-literature
Transcriptomics Metabolomic heterogeneity of severe pulmonary arterial hypertension
2014-11-14 | E-GEOD-53408 | biostudies-arrayexpress
Unknown Colorectal Pulmonary Metastases: Pulmonary Metastasectomy or Stereotactic Radiotherapy?
| S-EPMC10647532 | biostudies-literature
Proteomics Heart ventricles proteomic profile in pulmonary arterial hypertension
2020-09-07 | PXD015896 | Pride
Transcriptomics Investigation of endothelial cell gene dysregulation in early pulmonary arterial hypertension disease model
2014-02-06 | E-GEOD-42767 | biostudies-arrayexpress