Functional Validation of Doxorubicin-Induced Cardiotoxicity-Related Genes.

ABSTRACT:

Background

Genome-wide association studies and candidate gene association studies have identified more than 180 genetic variants statistically associated with anthracycline-induced cardiotoxicity (AIC). However, the lack of functional validation has hindered the clinical translation of these findings.

Objectives

The aim of this study was to functionally validate all genes associated with AIC using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).

Methods

Through a systemic literature search, 80 genes containing variants significantly associated with AIC were identified. Additionally, 3 more genes with potential roles in AIC (GSTM1, CBR1, and ERBB2) were included. Of these, 38 genes exhibited expression in human fetal heart, a

SUBMITTER: Fonoudi H 

PROVIDER: S-EPMC10950437 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature