Lactate administration improves laboratory parameters in murine models of iron overload.

ABSTRACT:

Abstract

Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in β-thalassemic mice.

SUBMITTER: Liu W 

PROVIDER: S-EPMC10950472 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature