Spatially Conserved Spiral Wave Activity During Human Atrial Fibrillation.

ABSTRACT:

Background

Atrial fibrillation is the most common cardiac arrhythmia in the world and increases the risk for stroke and morbidity. During atrial fibrillation, the electric activation fronts are no longer coherently propagating through the tissue and, instead, show rotational activity, consistent with spiral wave activation, focal activity, collision, or partial versions of these spatial patterns. An unexplained phenomenon is that although simulations of cardiac models abundantly demonstrate spiral waves, clinical recordings often show only intermittent spiral wave activity.

Methods

In silico data were generated using simulations in which spiral waves were continuously created and annihilated and in simulations in which a spiral wave was intermittently trapped at a heterogene

SUBMITTER: Rappel WJ 

PROVIDER: S-EPMC10950516 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature