Quantification of whole-organ individual and bilateral renal metabolic rate of oxygen.

ABSTRACT:

Purpose

Renal metabolic rate of oxygen (rMRO₂ ) is a potentially important biomarker of kidney function. The key parameters for rMRO₂ quantification include blood flow rate (BFR) and venous oxygen saturation (SvO₂ ) in a draining vessel. Previous approaches to quantify renal metabolism have focused on the single organ. Here, both kidneys are considered as one unit to quantify bilateral rMRO₂ . A pulse sequence to facilitate bilateral rMRO₂ quantification is introduced.

Methods

To quantify bilateral rMRO₂ , measurements of BFR and SvO₂ are made along the inferior vena cava (IVC) at suprarenal and infrarenal locations. From the continuity equation, these four parameters can be related to derive an exp

SUBMITTER: Deshpande RS 

PROVIDER: S-EPMC10950521 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature