Modulation of potassium channels by transmembrane auxiliary subunits via voltage-sensing domains.

ABSTRACT: Voltage-gated K⁺ (K_V ) and Ca²⁺ -activated K⁺ (K_Ca ) channels are essential proteins for membrane repolarization in excitable cells. They also play important physiological roles in non-excitable cells. Their diverse physiological functions are in part the result of their auxiliary subunits. Auxiliary subunits can alter the expression level, voltage dependence, activation/deactivation kinetics, and inactivation properties of the bound channel. K_V and K_Ca channels are activated by membrane depolarization through the voltage-sensing domain (VSD), so modulation of K_V and K_Ca channels through the VSD is reasonable. Recent cryo-EM structures of the K_V or K_Ca channel complex wi

SUBMITTER: Nakajo K 

PROVIDER: S-EPMC10950684 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature