Return of polygenic risk scores in research: Stakeholders' views on the eMERGE-IV study.

ABSTRACT: Research on polygenic risk scores (PRSs) for common, genetically complex chronic diseases aims to improve health-related predictions, tailor risk-reducing interventions, and improve health outcomes. Yet, the study and use of PRSs in clinical settings raise equity, clinical, and regulatory challenges that can be greater for individuals from historically marginalized racial, ethnic, and other minoritized communities. As part of the National Human Genome Research Institute-funded Electronic Medical Records and Genomics IV Network, we conducted online focus groups with patients/community members, clinicians, and members of institutional review boards to explore their views on key issues, including PRS research, return of PRS results, clinical translation, and barriers and facilitators to healt

SUBMITTER: Sabatello M 

PROVIDER: S-EPMC10950748 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature