Genetic evidence for the causal effects of C-reactive protein on self-reported habitual sleep duration.

ABSTRACT: Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg/L has a homeostatic effect that facilitates maintaining 7-8 h sleep duration per day - making short-sleepers sleep longer (p = 2.42 × 10^-2) and long-sleepers sleep shorter (1.87 × 10^-7); but it is not associated with the overall sleep duration (p = 0.17). This homeostatic effect replicated in an independent CRP dataset. We observed causal effects of the soluble interleukin 6

SUBMITTER: Iakunchykova O 

PROVIDER: S-EPMC10950822 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature