Development of an explainable AI system using routine clinical parameters for rapid differentiation of inflammatory conditions.

ABSTRACT:

Introduction

Inflammatory conditions in patients have various causes and require different treatments. Bacterial infections are treated with antibiotics, while these medications are ineffective against viral infections. Autoimmune diseases and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, require immunosuppressive therapies such as glucocorticoids, which may be contraindicated in other inflammatory states. In this study, we employ a combination of straightforward blood tests to devise an explainable artificial intelligence (XAI) for distinguishing between bacterial infections, viral infections, and autoimmune diseases/graft-versus-host disease.

Patients and methods

We analysed peripheral blood from 80 patients with inflammatory conditions and 3

SUBMITTER: Hoffmann J 

PROVIDER: S-EPMC10950914 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature