Precursor exhausted CD8⁺T cells in colorectal cancer tissues associated with patient's survival and immunotherapy responsiveness.

ABSTRACT: Exhausted CD8⁺T cells represent a distinct cellular lineage that emerges during both chronic infections and cancers. Recent studies have shown that persistent antigen exposure can drive the differentiation of precursor exhausted CD8⁺T cells, termed T_pex cells, which are characterized as TCF-1⁺PD-1⁺CD8⁺T cells. Elevated T_pex cell frequencies in the tumor microenvironment (TME) are associated with improved overall survival (OS) in cancer patients and heightened responsiveness to anti-PD-1 therapy. In our present study, we utilized multi-color immunohistochemistry (mIHC) to determine the localization and clinical implications of tumor-infiltrating T_pex cells within the TME of human colorectal cancer (CRC)

SUBMITTER: Huang H 

PROVIDER: S-EPMC10950923 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature