Clinical significance of regional constructive and wasted work in patients receiving cardiac resynchronization therapy.

ABSTRACT:

Background

Previous studies have shown that global constructive work (CW) and wasted work (WW) predict response to cardiac resynchronization therapy (CRT). This study evaluated the predictive value of regional CW and WW for reverse remodeling and clinical outcomes after CRT.

Methods

We performed a prospective study involving 134 CRT candidates with left bundle branch block and left ventricular ejection fraction ≤35%. Global and regional CW and WW were calculated using pressure-strain loop analysis. CRT response was defined by reverse remodeling as a reduction of ≥15% in left ventricular end-systolic volume after six months.

Results

At six-month follow-up, 92 (69%) patients responded to CRT. Of the regional CW and WW measures, lateral wall (LW) CW and septal WW were mo

SUBMITTER: Wang CL 

PROVIDER: S-EPMC10950977 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature