Real-World Use of Oral and Subcutaneous Semaglutide in Routine Clinical Practice in the UK: A Single-Centre, Retrospective Observational Study.

ABSTRACT:

Introduction

Semaglutide, the only glucagon-like peptide-1 receptor agonist (GLP-1 RA) available in subcutaneous and oral formulation for treatment of type 2 diabetes (T2D), has demonstrated clinically significant improvements in glycaemic control and weight in clinical trials. This study aimed to gain insights into the use of both formulations and evaluate their clinical effectiveness in a secondary care clinic in Wales.

Methods

This was a retrospective observational analysis of adults with T2D initiated on oral or subcutaneous semaglutide. Changes from baseline in glycated haemoglobin (HbA_1c), weight and other metabolic parameters were evaluated.

Results

At baseline, participants (n = 103) had a mean age of 57.3 years, mean HbA_1c of 79.1 mmol/m

SUBMITTER: Roy Chowdhury S 

PROVIDER: S-EPMC10951141 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature