SV2B/miR-34a/miR-128 axis as prognostic biomarker in glioblastoma multiforme.

ABSTRACT: Glioblastoma (GBM) is a heterogenous primary brain tumour that is characterised with unfavourable patient prognosis. The identification of biomarkers for managing brain malignancies is of utmost importance. MicroRNAs (miRNAs) are small, non-coding RNAs implicated in cancer development. This study aimed to assess the prognostic significance of miRNAs and their gene targets in GBM. An in silico approach was employed to investigate the differentially expressed miRNAs in GBM. The most dysregulated miRNAs were identified and analysed via Sfold in association with their gene target. The candidate gene was studied via multi-omics approaches, followed by in vitro and in vivo experiments. The in silico analyses revealed that miR-128a and miR-34a were significantly downregulated within GBM. Both miR

SUBMITTER: Mustafov D 

PROVIDER: S-EPMC10951322 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature