MicroRNAs as biomarkers of brain injury in neonatal encephalopathy: an observational cohort study.

ABSTRACT: Neonatal Encephalopathy (NE) is a major cause of lifelong disability and neurological complications in affected infants. Identifying novel diagnostic biomarkers in this population may assist in predicting MRI injury and differentiate neonates with NE from those with low-cord pH or healthy neonates and may help clinicians make real-time decisions. To compare the microRNA (miRNA) profiles between neonates with NE, healthy controls, and neonates with low cord pH. Moreover, miRNA concentrations were compared to brain injury severity in neonates with NE. This is a retrospective analysis of miRNA profiles from select samples in the biorepository and data registry at the University of Florida Health Gainesville. The Firefly miRNA assay was used to screen a total of 65 neurological miRNA targets i

SUBMITTER: Dakroub F 

PROVIDER: S-EPMC10951356 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature