Role of toll-like receptor 4 in skeletal muscle damage in chronic limb-threatening ischemia.

ABSTRACT:

Objective

Toll-like receptors (TLRs) are key pattern recognition receptors in the innate immune system. In particular, the TLR4-mediated immune response has been implicated in ischemia-induced tissue injury. Mounting evidence supports a detrimental role of the innate immune system in the pathophysiology of skeletal muscle damage in patients with chronic limb-threatening ischemia (CLTI), in whom patient-oriented functional outcomes are poor. The overall aim of this study was to investigate the potential role of TLR4 in skeletal muscle dysfunction and damage in CLTI.

Methods

The role of TLR4 in ischemic muscle was investigated by (1) studying TLR4 expression and distribution in human gastrocnemius muscle biopsies, (2) evaluating the functional consequences of TLR4 inhibition i

SUBMITTER: Navi A 

PROVIDER: S-EPMC10951510 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature