Toll-like receptor 6 inhibits colorectal cancer progression by suppressing NF-κB signaling.

ABSTRACT:

Background

Toll-like receptors (TLRs) are implicated in the pathogenesis and progression of inflammation-associated cancers, except their role in regulating innate immunity. Specifically, a berrant expression of TLR6 has been observed in colorectal cancers (CRC). However, the effect of abnormal TLR6 expression on CRC remians unclear. Therefore, the present study evaluated TLR6 expression in CRC, its effect on CRC proliferation, and its underlying mechanism.

Methods

The expression of TLR6 in CRC was assessed using data from TCGA, GTEx, and HPA datasets and immunohistochemical assays of tumor tissues from patients with CRC. In human CRC cell lines, TLR6 signaling was activated using the TLR6 agonist Pam2CSK4 and was blocked using antiTLR6-IgG; subsequently, cell growth, migrat

SUBMITTER: Ma L 

PROVIDER: S-EPMC10951511 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature