Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma.

ABSTRACT: Meningiomas are among the most prevalent primary CNS tumors in adults, accounting for nearly 38% of all brain neoplasms. The World Health Organization (WHO) grade assigned to meningiomas guides medical care in patients and is primarily based on tumor histology and malignancy potential. Although often considered benign, meningiomas with complicated histology, limited accessibility for surgical resection, and/or higher malignancy potential (WHO grade 2 and WHO grade 3) are harder to combat, resulting in significant morbidity. With limited treatment options and no systemic therapies, it is imperative to understand meningioma tumorigenesis at the molecular level and identify novel therapeutic targets. The last decade witnessed considerable progress in understanding the noncoding RNA landscape

SUBMITTER: Joshi R 

PROVIDER: S-EPMC10951709 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature