Prognostic Significance of Serum Interleukin-6 Levels in Oral Squamous Cell Carcinoma.

ABSTRACT: Introduction The prognosis of oral squamous cell carcinoma (OSCC) is often poor despite standard treatments. Additionally, no useful prognostic markers are available. Therefore, we aimed to investigate the relationship between serum Interleukin-6 (IL-6) levels and prognosis and explore its local and systemic effects in patients with OSCC. Methods Ninety-five new cases of OSCC were included, and the prognosis was compared between high and low serum IL-6 groups. The localization of IL-6 in OSCC tissues was examined. Furthermore, a comprehensive gene expression analysis was performed in OSCC tissues and compared between the two groups. Results A significant difference in overall survival and disease-free survival was observed. Furthermore, a substantial expression of IL-6 was localized in the

SUBMITTER: Adachi T 

PROVIDER: S-EPMC10951754 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature