Dysregulation of calcium homeostasis in cancer and its role in chemoresistance.

ABSTRACT: Globally, cancer, as a major public health concern, poses a severe threat to people's well-being. Advanced and specialized therapies can now cure the majority of people with early-stage cancer. However, emerging resistance to traditional and novel chemotherapeutic drugs remains a serious issue in clinical medicine. Chemoresistance often leads to cancer recurrence, metastasis, and increased mortality, accounting for 90% of chemotherapy failures. Thus, it is important to understand the molecular mechanisms of chemoresistance and find novel therapeutic approaches for cancer treatment. Among the several factors responsible for chemoresistance, calcium (Ca²⁺) dysregulation plays a significant role in cancer progression and chemoresistance. Therefore, targeting this derailed Ca²⁺

SUBMITTER: Kumari N 

PROVIDER: S-EPMC10951838 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature