Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults.

ABSTRACT:

Importance

Among critically ill adults, randomized trials have not found oxygenation targets to affect outcomes overall. Whether the effects of oxygenation targets differ based on an individual's characteristics is unknown.

Objective

To determine whether an individual's characteristics modify the effect of lower vs higher peripheral oxygenation-saturation (Spo2) targets on mortality.

Design, setting, and participants

A machine learning model to predict the effect of treatment with a lower vs higher Spo2 target on mortality for individual patients was derived in the Pragmatic Investigation of Optimal Oxygen Targets (PILOT) trial and externally validated in the Intensive Care Unit Randomized Trial Comparing Two Approaches to Oxygen Therapy (ICU-ROX) trial. Critically il

SUBMITTER: Buell KG 

PROVIDER: S-EPMC10951851 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature