Presymptomatic Profiles of Cognitive Impairment with Prior Mobility Impairment.

ABSTRACT:

Objectives

To identify cognitive and health profiles of cognitively impaired older adults with the presence of prior mobility impairment, which may represent a specific pathway to the development of cognitive impairment or dementia.

Design

Retrospective longitudinal study.

Setting and participants

In adults aged ≥65 years who developed cognitive impairment or dementia, we compared cognitive and health profiles of those who did (n = 57) and did not (n = 86) experience slow gait up to 14 years before symptom onset. Measures of cognitive and biomarkers assessed longitudinally over an average of 7 years before symptom onset were compared between groups using linear mixed effects models, adjusted age, sex, race, and additionally adjusted for education for cognitive outcome

SUBMITTER: Tian Q 

PROVIDER: S-EPMC10951864 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature