VistoSeg: Processing utilities for high-resolution images for spatially resolved transcriptomics data.

ABSTRACT: Spatially resolved transcriptomics (SRT) is a growing field that links gene expression to anatomical context. SRT approaches that use next-generation sequencing (NGS) combine RNA sequencing with histological or fluorescent imaging to generate spatial maps of gene expression in intact tissue sections. These technologies directly couple gene expression measurements with high-resolution histological or immunofluorescent images that contain rich morphological information about the tissue under study. While broad access to NGS-based spatial transcriptomic technology is now commercially available through the Visium platform from the vendor 10× Genomics, computational tools for extracting image-derived metrics for integration with gene expression data remain limited. We developed VistoSeg

SUBMITTER: Tippani M 

PROVIDER: S-EPMC10951916 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature