Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery.

ABSTRACT: Microneedle-based drug delivery offers an attractive and minimally invasive administration route to deliver therapeutic agents through the skin by bypassing the stratum corneum, the main skin barrier. Recently, hydrogel-based microneedles have gained prominence for their exceptional ability to precisely control the release of their drug cargo. In this study, we investigated the feasibility of fabricating microneedles from triblock amphiphiles with linear poly(ethylene glycol) (PEG) as the hydrophilic middle block and two dendritic side-blocks with enzyme-cleavable hydrophobic end-groups. Due to the poor formation and brittleness of microneedles made from the neat amphiphile, we added a sodium alginate base layer and tested different polymeric excipients to enhance the mechanical strength o

SUBMITTER: Dawud H 

PROVIDER: S-EPMC10951948 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature