Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study.

ABSTRACT:

Background

Many observational studies support light-to-moderate alcohol intake as potentially protective against premature death. We used a genetic approach to evaluate the linear and nonlinear relationships between alcohol consumption and mortality from different underlying causes.

Methods

We used data from 278 093 white-British UK Biobank participants, aged 37-73 years at recruitment and with data on alcohol intake, genetic variants, and mortality. Habitual alcohol consumption was instrumented by 94 variants. Linear Mendelian randomization (MR) analyses were conducted using five complementary approaches, and nonlinear MR analyses by the doubly-ranked method.

Results

There were 20 834 deaths during the follow-up (median 12.6 years). In conventional analysis, the asso

SUBMITTER: Kassaw NA 

PROVIDER: S-EPMC10951973 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature