ΔNp63 regulates MDSC survival and metabolism in triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) contributes greatly to mortality of breast cancer, demanding new targetable options. We have shown that TNBC patients have high ΔNp63 expression in tumors. However, the function of ΔNp63 in established TNBC is yet to be explored. In current studies, targeting ΔNp63 with inducible CRISPR knockout and Histone deacetylase inhibitor Quisinostat showed that ΔNp63 is important for tumor progression and metastasis in established tumors by promoting myeloid-derived suppressor cell (MDSC) survival through tumor necrosis factor alpha. Decreasing ΔNp63 levels are associated with decreased CD4⁺ and FOXP3⁺ T-cells but increased CD8⁺ T-cells. RNA sequencing analysis indicates that loss of ΔNp63 alters multiple MDSC properties s

SUBMITTER: Kim U 

PROVIDER: S-EPMC10951988 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature