Dynamic immune recovery process after liver transplantation revealed by single-cell multi-omics analysis.

ABSTRACT: Elucidating the temporal process of immune remodeling under immunosuppressive treatment after liver transplantation (LT) is critical for precise clinical management strategies. Here, we performed a single-cell multi-omics analysis of peripheral blood mononuclear cells (PBMCs) collected from LT patients (with and without acute cellular rejection [ACR]) at 13 time points. Validation was performed in two independent cohorts with additional LT patients and healthy controls. Our study revealed a four-phase recovery process after LT and delineated changes in immune cell composition, expression programs, and interactions along this process. The intensity of the immune response differs between the ACR and non-ACR patients. Notably, the newly identified inflamed NK cells, CD14⁺RNASE2

SUBMITTER: Wang R 

PROVIDER: S-EPMC10952083 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature