Proteome profiling of salivary small extracellular vesicles in glioblastoma patients.

ABSTRACT:

Background

Extracellular vesicles (EVs) play a critical role in intercellular communication under physiological and pathological conditions, including cancer. EVs cargo reflects their cell of origin, suggesting their utility as biomarkers. EVs are detected in several biofluids, and their ability to cross the blood-brain barrier has highlighted their potential as prognostic and diagnostic biomarkers in gliomas, including glioblastoma (GBM). Studies have demonstrated the potential clinical utility of plasma-derived EVs in glioma. However, little is known about the clinical utility of saliva-derived EVs in GBM.

Methods

Small EVs were isolated from whole mouth saliva of GBM patients pre- and postoperatively. Isolation was performed using differential centrifugation and/or ultrac

SUBMITTER: Muller Bark J 

PROVIDER: S-EPMC10952188 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature