α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping.

ABSTRACT: A general and straightforward procedure for the lithiation trapping of cyclic sulfides such as tetrahydrothiophene, tetrahydrothiopyran and a thiomorpholine is described. Trapping with a wide range of electrophiles is demonstrated, leading to more than 50 diverse α-substituted saturated sulfur heterocycles. The methodology provides access to a range of α-substituted cyclic sulfides that are not easily synthesised by the currently available methods.

SUBMITTER: Seling N 

PROVIDER: S-EPMC10952194 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature