What determines the optimal pharmacological treatment of atrial fibrillation? Insights from in silico trials in 800 virtual atria.

ABSTRACT: The best pharmacological treatment for each atrial fibrillation (AF) patient is unclear. We aim to exploit AF simulations in 800 virtual atria to identify key patient characteristics that guide the optimal selection of anti-arrhythmic drugs. The virtual cohort considered variability in electrophysiology and low voltage areas (LVA) and was developed and validated against experimental and clinical data from ionic currents to ECG. AF sustained in 494 (62%) atria, with large inward rectifier K⁺ current (I_K1 ) and Na⁺ /K⁺ pump (I_NaK ) densities (I_K1 0.11 ± 0.03 vs. 0.07 ± 0.03 S mF^-1 ; I_NaK 0.68 ± 0.15 vs. 0.38 ± 26 S mF^-1 ; sustained vs. un-sustained AF). In severely remodelled left atrium, with

SUBMITTER: Dasi A 

PROVIDER: S-EPMC10952228 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature