Endothelial PAR2 activation evokes resistance artery relaxation.

ABSTRACT: Protease-activated receptor-1 & -2 (PAR1 and PAR2) are expressed widely in cardiovascular tissues including endothelial and smooth muscle cells. PAR1 and PAR2 may regulate blood pressure via changes in vascular contraction or relaxation mediated by endothelial Ca²⁺ signaling, but the mechanisms are incompletely understood. By using single-cell Ca²⁺ imaging across hundreds of endothelial cells in intact blood vessels, we explored PAR-mediated regulation of blood vessel function using PAR1 and PAR2 activators. We show that PAR2 activation evoked multicellular Ca²⁺ waves that propagated across the endothelium. The PAR2-evoked Ca²⁺ waves were temporally distinct from those generated by muscarinic receptor activation. PAR2 activated distinct clusters

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10952239 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature